Fases iniciales de la psicosis
Actividades del grupo
Los trastornos psicóticos son enfermedades mentales de elevada gravedad y cronicidad que afectan aproximadamente al 2,5% de la población, produciendo importantes costes personales y asistenciales.
Los principales objetivos de este equipo son:
Identificar factores pronóstico relevantes que permitan orientar el diseño de intervenciones para mejorar el curso de la enfermedad.
Identificar marcadores endofenotípicos que ayuden a los clínicos a apoyar de forma más fiable un diagnóstico psicótico específico durante las fases tempranas.
Determinar la presencia de un posible factor biológico que explique la alta prevalencia de consumo de tabaco en esta población y orientar intervenciones sobre esta adicción.
Definir el perfil de afectación cognitiva y su evolución tanto en fases tempranas como en pacientes crónicos y valorar la eficacia de la rehabilitación cognitiva como una posible herramienta terapéutica.
Esperamos obtener resultados que además de ofrecer una mayor comprensión sobre los mecanismos de la enfermedad, permitan diseñar nuevas estrategias de intervención destinadas a incrementar la salud y calidad de vida de estos pacientes.
Coordinador/a del grupo
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Rafael Segarra Echevarria
Coordinador de grupo
rafael.segarraechevarria@osakidetza.eus
CV resumen
Miembros del grupo
Publicaciones del grupo
Odagaki Y, Mikami M, Kinoshita M, Meana JJ, Callado LF, Garcia Sevilla JA, et al. Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPgammaS binding assay. Pharmacol Rep. 2023. DOI:10.1007/s43440-023-00448-6.
Yanez Gomez F, Ramos Miguel A, Garcia Sevilla JA, Manzanares J, Femenia T. Regulation of Cortico-Thalamic JNK1/2 and ERK1/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress. Int J Mol Sci. 2023; 24(3). DOI:10.3390/ijms24032303.
Nunez delMoral A, Bianchi PC, Brocos Mosquera I, Anesio A, Palombo P, Camarini R, et al. The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder. Biomolecules. 2023; 13(2). DOI:10.3390/biom13020234.
Villa M, Martinez Vega M, Del Pozo A, Muneta Arrate I, Gomez Soria A, Muguruza C, et al. The Role of the Dopamine System in Post-Stroke Mood Disorders in Newborn Rats. Int J Mol Sci. 2023; 24(4). DOI:10.3390/ijms24043229.
Miquel Rio L, Sarries Serrano U, Pavia Collado R, Meana JJ, Bortolozzi A. The Role of alpha-Synuclein in the Regulation of Serotonin System: Physiological and Pathological Features. Biomedicines. 2023; 11(2). DOI:10.3390/biomedicines11020541.
Iglesias Tejedor M, Diez A, Llorca Bofi V, Nunez P, Castano Diaz C, Bote B, et al. Relation between EEG resting-state power and modulation of P300 task-related activity in theta band in schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry. 2022; 116: 110541-110541. DOI:10.1016/j.pnpbp.2022.110541.
Navines R, Oriolo G, Horrillo I, Cavero M, Aouizerate B, Schaefer M, et al. High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers. Int J Neuropsychopharmacol. 2022; 25(6): 468-478. DOI:10.1093/ijnp/pyac016.
Catalan A, Aymerich C, Bilbao A, Pedruzo B, Pérez JL, Aranguren N, et al. Psychosis and Substance Abuse increase the COVID-19 mortality risk. Psychol Med. 2022: 1-9. DOI:10.1017/S0033291722000976.
Almodovar Paya C, Guardiola Ripoll M, Giralt Lopez M, Gallego C, Salgado Pineda P, Miret S, et al. NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches. Int J Mol Sci. 2022; 23(13). DOI:10.3390/ijms23137456.
Erkizia Santamaria I, Alles Pascual R, Horrillo I, Meana JJ, Ortega JE. Serotonin 5-HT2A, 5-HT2c and 5-HT1A receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response. Biomed Pharmacother. 2022; 154: 113612-113612. DOI:10.1016/j.biopha.2022.113612.
Martinez Torres S, Bergada Martinez A, Ortega JE, Galera Lopez L, Hervera A, de los Reyes Ramirez L, et al. Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism. Neuropsychopharmacology. 2022; 48(2): 341-350. DOI:10.1038/s41386-022-01436-9.
Saunders JM, Muguruza C, Sierra S, Moreno JL, Callado LF, Meana JJ, et al. Glucocorticoid receptor dysregulation underlies 5-HT2AR-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model. J Biol Chem. 2022; 298(11): 102481-102481. DOI:10.1016/j.jbc.2022.102481.
Blanco Rey M, Castrillo Bodero R, Ali K, Gargiani P, Bertran F, Sheverdyaeva PM, et al. Effect of the valence state on the band magnetocrystalline anisotropy in two-dimensional rare-earth/noble-metal compounds. Phys Rev Res. 2022; 4(1). DOI:10.1103/PhysRevResearch.4.013237.
Costas Insua C, Hermoso Lopez A, Moreno E, Alvaro Blazquez A, Montero C, Martin Gutierrez D, et al. CB1R as a potential therapeutic target in CRBN deficiency-associated mental retardation. FEBS Open Bio. 2022; 12: 202-202
Molina V, Fernandez Linsenbarth I, Queipo Llano M, Jimenez Aparicio MT, Vallecillo Adame C, Aremy Gonzaga A, et al. Real-life outcomes in biotypes of psychotic disorders based on neurocognitive performance. Eur Arch Psych Clin Neurosci. 2022. DOI:10.1007/s00406-022-01518-1.
Casaletto K, Ramos Miguel A, VandeBunte A, Memel M, Buchman A, Bennett D, et al. Late-life physical activity relates to brain tissue synaptic integrity markers in older adults. Alzheimers Dement. 2022; 18(11): 2023-2035. DOI:10.1002/alz.12530.
Ibarra Lecue I, Diez Alarcia R, Uriguen L. Serotonin 2A receptors and cannabinoids. Prog Brain Res. 2021; 259: 135-175. DOI:10.1016/bs.pbr.2021.01.004.
Fernandez Abascal B, Recio Barbero M, Saenz Herrero M, Segarra R. Long-acting injectable aripiprazole in pregnant women with schizophrenia: a case-series report. Ther Adv Psychopharm. 2021; 11. DOI:10.1177/2045125321991277.
Soria Gomez E, Pagano Zottola AC, Mariani Y, Desprez T, Barresi M, Bonilla Del Rio I et al. Subcellular specificity of cannabinoid effects in striatonigral circuits. Neuron. 2021; 109(9). DOI:10.1016/j.neuron.2021.03.007.
Muneta Arrate I, Diez Alacia R, Horillo I, Meana JJ. Enhanced coupling of the 5-HT2A receptor with G alpha i1-protein in post-mortem frontal cortex of subjects with schizophrenia. Eur Neuropsychopharmacol. 2021; 44: 4-4. DOI:10.1016/j.euroneuro.2021.01.012.
Odagaki Y, Kinoshita M, Meana JJ, Callado LF, Garcia Sevilla JA. 5-HT2A receptor- and M-1 muscarinic acetylcholine receptor-mediated activation of G alpha(q/11) in postmortem dorsolateral prefrontal cortex of opiate addicts. Pharmacol Rep. 2021; 73(4): 1155-1163. DOI:10.1007/s43440-021-00248-w.
Diez Alarcia R, Odagaki Y, Miranda Azpiazu P, Gabilondo AM, Meana JJ, Muneta Arrate I. Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [35S]GTPgammaS binding assays combined with immunoprecipitation. Pharmacol Rep. 2021; 73(4): 1079-1095. DOI:10.1007/s43440-021-00253-z.
Recio Barbero M, Segarra R, Zabala A, Gonzalez Fraile E, Gonzalez Pinto A, Ballesteros J. Cognitive Enhancers in Schizophrenia: A Systematic Review and Meta-Analysis of Alpha-7 Nicotinic Acetylcholine Receptor Agonists for Cognitive Deficits and Negative Symptoms. Front Psychiatry. 2021; 12: 631589-631589. DOI:10.3389/fpsyt.2021.631589.
Nunez delMoral A, Brocos Mosquera I, Vialou V, Callado LF, Erdozain AM. Characterization of hevin (SPARCL1) immunoreactivity in postmortem human brain homogenates. Neuroscience. 2021; 467: 91-109. DOI:10.1016/j.neuroscience.2021.05.017.
Diez Alarcia R, Muguruza C, Rivero G, Garcia Bea A, Gomez Vallejo V, Callado LF et al. Opposite alterations of 5-HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile. Transl Psychiatr. 2021; 11(1): 302-302. DOI:10.1038/s41398-021-01430-7.
Segarra R, Recio Barbero M, Saenz Herrero M, Mentxaka O, Cabezas Garduno J, Eguiluz JI et al. Oral and Palmitate Paliperidone Long-Acting Injectable Formulations use in Schizophrenia Spectrum Disorders: a retrospective cohort study from the CRUPEP First Episode Psychosis Intervention Program. Int J Neuropsychopharmacol. 2021; 24(9): 694-702. DOI:10.1093/ijnp/pyab021.
Diez Alarcia R, Odagaki Y, Miranda Azpiazu P, GABILONDO AM, Meana JJ, Muneta Arrate I. Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [S-35]GTP gamma S binding assays combined with immunoprecipitation (Apr, 10.1007/s43440-021-00253-z, 2021). Pharmacol Rep. 2021; 73(4): 1203-1203. DOI:10.1007/s43440-021-00268-6.
MacDowell KS, Munarriz Cuezva E, Meana JJ, Leza JC, Ortega JE. Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways. Front Pharmacol. 2021; 12: 682602-682602. DOI:10.3389/fphar.2021.682602.
Egusquiza I, Munarriz Cuezva E, Segarra R, Gonzalez Maeso J, Callado LF, Meana JJ et al. Characterization of dopamine D-2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia. Pharmacol Rep. 2021; 73(4): 1136-1146. DOI:10.1007/s43440-021-00305-4.
Brocos Mosquera I, Gabilondo AM, Diez Alarcia R, Muguruza C, Erdozain AM, Meana JJ et al. alpha2A- and alpha2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects. Eur Neuropsychopharmacol. 2021; 52: 3-11. DOI:10.1016/j.euroneuro.2021.05.012.
Nunez delMoral A, Brocos Mosquera I, Vialou V, Callado LF, Erdozain AM. The matricellular protein hevin is overexpressed in alcoholism: a study in postmortem human brain. Eur Neuropsychopharmacol. 2021; 44: 8-8. DOI:10.1016/j.euroneuro.2021.01.017.
Rodriguez Arevalo S, Bagan A, Grinan Ferre C, Vasilopoulou F, Pallas M, Brocos Mosquera I et al. Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease. Eur J Med Chem. 2021; 222: 113540-113540. DOI:10.1016/j.ejmech.2021.113540.
Odagaki Y, Meana JJ. Special issue "role of G-proteins and GPCR-mediated signaling in the pathophysiology and treatment of psychiatric disorders". Pharmacol Rep. 2021; 73(4): 967-969. DOI:10.1007/s43440-021-00313-4.
Lopez Atanes M, Pijoan Zubizarreta JI, Gonzalez Briceno JP, Leones Gil EM, Recio Barbero M, Gonzalez Pinto A et al. Gender-Based Analysis of the Psychological Impact of the COVID-19 Pandemic on Healthcare Workers in Spain. Front Psychiatry. 2021; 12: 692215-692215. DOI:10.3389/fpsyt.2021.692215.
Turuelo M, Acera A, Diez Cirarda M, Fernandez T, Tijero B, Carmona M et al. Visual cognition differences between asymptomatic and symptomatic carriers of Huntington's disease (HD). Mov Disord. 2021; 36: 113-113
Moreno M, Ortiz R, Almodovar Paya C, Guardiola Ripoll M, Callado LF, Fatjo Vilas M et al. NRN1 EXPRESSION IN BRAIN: ANALYSIS IN INDIVIDUALS DIAGNOSED WITH SCHIZOPHRENIA PATIENTS AND HEALTHY SUBJECTS. Eur Neuropsychopharmacol. 2021; 51: 235-236. DOI:10.1016/j.euroneuro.2021.08.248.
Costas Insua C, Moreno E, Maroto IB, Ruiz Calvo A, Bajo Graneras R, Martin Gutierrez D et al. Identification of BiP as a CB1 Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain. J Neurosci. 2021; 41(38): 7924-7941. DOI:10.1523/JNEUROSCI.0821-21.2021.
Gonzalez Ortega I, Alberich Mesa S, Echeburua E, Bernardo M, Cabrera B, Amoretti S et al. Social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis. Eur Psychiat. 2021; 64: 163-163. DOI:10.1192/j.eurpsy.2021.436.
Recio Barbero M, Santorcuato A, Bacigalupe A, Lopez Atanes M, Fuertes Soriano S, Cabezas Garduno J et al. Gender differences among psychiatric patients attended in a emergency department. Eur Psychiat. 2021; 64: 600-600. DOI:10.1192/j.eurpsy.2021.1600.
Fernandez Linsenbarth I, Planchuelo Gomez A, Beno Sierra RM, Diez A, Arjona A, Perez A et al. Search for schizophrenia and bipolar biotypes using functional network properties. Brain Behav. 2021; 11(12). DOI:10.1002/brb3.2415.
Brocos Mosquera I, Miranda Azpiazu P, Muguruza C, Corzo Monje V, Morentin B, Meana JJ et al. Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment. Transl Psychiatr. 2021; 11(1). DOI:10.1038/s41398-021-01762-4.
Lopez Atanes M, Gonzalez Briceno JP, Abeal Adham A, Fuertes Soriano S, Cabezas Garduno J, Pena Rotella A et al. Liaison Psychiatry During the Peak of the Coronavirus Pandemic: A Description of Referrals and Interventions. Front Psychiatry. 2021; 12. DOI:10.3389/fpsyt.2021.555080.
Cordero Ruiz N, Meana JJ, Muguruza C, Ortega JE. Molecular evaluation of neuroinflammatory signaling in a double-hit mouse model of cognitive deficits of schizophrenia. Eur Neuropsychopharmacol. 2021; 53: 401-402. DOI:10.1016/j.euroneuro.2021.10.515.
DelaCuesta Barrutia J, Penagarikano O, Morentin B, Callado LF, Meana JJ, Erdozain AM et al. Dopamine D2, cannabinoid CB1, metabotropic glutamate mGlu2 and mGlu3 receptor protein expression in the prefrontal cortex of subjects with schizophrenia. Eur Neuropsychopharmacol. 2021; 53: 356-357. DOI:10.1016/j.euroneuro.2021.10.456.
Erkizia Santamaria I, Alles Pascual R, Horrillo I, Meana JJ, Ortega JE. Evaluation of the acute mechanism of action of psilocybin in mice. Eur Neuropsychopharmacol. 2021; 53: 215-216. DOI:10.1016/j.euroneuro.2021.10.282.
Martinez Peula O, Rivero G, Diaz Grijuela E, Munarriz Cuezva E, Erdozain AM, Meana JJ et al. Selective downregulation of cortical mglu2 receptors in the maternal immune activation model of schizophrenia: association with histone posttranslational modifications. Eur Neuropsychopharmacol. 2021; 53: 214-215. DOI:10.1016/j.euroneuro.2021.10.281.
Meana JJ, Muneta Arrate I, Horrillo I, Diez Alarcia R. Increased serotonin 5HT2A receptor constitutive activity on G alpha i1-but not G alpha q/11-proteins in human prefrontal cortex of subjects with schizophrenia. Eur Neuropsychopharmacol. 2021; 53: 447-448. DOI:10.1016/j.euroneuro.2021.10.574.
Munarriz Cuezva E, Cordero Ruiz N, Martinez Peula O, Unzueta Larrinaga P, Meana JJ. Weight and temperature monitoring of pregnant dams in the poly(I:C) maternal immune activation model of schizophrenia. Strain and batch influence. Eur Neuropsychopharmacol. 2021; 53: 616-616. DOI:10.1016/j.euroneuro.2021.10.701.
Muneta Arrate I, Diez Alacia R, Horrillo I, Meana JJ. Evaluation of serotonin 5HT2A receptor functional selectivity and inverse agonist properties of different antipsychotic drugs in human post-mortem brain cortex. Eur Neuropsychopharmacol. 2021; 53: 165-166. DOI:10.1016/j.euroneuro.2021.10.219.
Recio Barbero M, Cabezas Garduno J, Ruiz Irastorza G, Horrillo I, Meana JJ, Gonzalez Melero MI et al. Mood and anxiety disorders in Systemic Lupus Erythematosus: results and insights from the Lupus-Cruces cohort. Eur Neuropsychopharmacol. 2021; 53: 538-539. DOI:10.1016/j.euroneuro.2021.10.805.
Unzueta Larrinaga P, Ibarra Lecue I, Barrena Barbadillo R, Diez Alarcia R, Landabaso MA, Mendibil B et al. Cannabis abuse differently regulates 5-HT2A receptors and Akt protein in platelets of subjects with schizophrenia. Eur Neuropsychopharmacol. 2021; 53: 666-667. DOI:10.1016/j.euroneuro.2021.10.763.
Nunez delMoral A, Bianchi PC, Cruz FC, Vialou V, Callado LF, Erdozain AM. Alcohol chronic administration and relapse alter the expression levels of the protein hevin in the nucleus accumbens in mice. Eur Neuropsychopharmacol. 2021; 53: 185-186. DOI:10.1016/j.euroneuro.2021.10.245.
González Ortega I, González Pinto A, Alberich S, Echeburúa E, Bernardo M, Cabrera B, et al. Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis. Psychol Med. 2020; 50(16): 1-9. DOI:10.1017/S0033291719002794.
Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García Sevilla JA. Functional coupling of M 1 muscarinic acetylcholine receptor to Ga q/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study. Eur Arch Psych Clin Neurosci. 2020; 270(7): 869-880. DOI:10.1007/s00406-019-01088-9.
Muneta Arrate I, Diez Alarcia R, Horrillo I, Meana JJ. Functional selectivity of different serotonin 5-HT2A receptor antagonists in human post-mortem brain cortex. Eur Neuropsychopharmacol. 2020; 31: 11-12. DOI:10.1016/j.euroneuro.2019.12.016.
Ibarra Lecue I, Diez Alarcia R, Morentin B, Meana JJ, Callado LF, Uriguen L. Ribosomal Protein S6 Hypofunction in Postmortem Human Brain Links mTORC1-Dependent Signaling and Schizophrenia. Front Pharmacol. 2020; 11: 344-344. DOI:10.3389/fphar.2020.00344.
Molina V, Lubeiro A, de Luis Garcia R, Gomez Pilar J, Martín Santiago O, Iglesias Tejedor M, et al. Deficits of entropy modulation of the EEG: A biomarker for altered function in schizophrenia and bipolar disorder?. J Psychiatry Neurosci. 2020; 45(3): 190032-190032. DOI:10.1503/jpn.190032.
Martinez Uribe D, Etxeandia Pradera JI, Bobes García J, Morán Barrios J, Ruiz de Gauna P, Sáenz Herrero M, et al. The training of Psychiatry resident: Summary of the discussion table held during the XXII National Congress of Psychiatry. Spain, 2019. Rev Psiquiatr Salud Ment. 2020; 14(1): 74-76. DOI:10.1016/j.rpsm.2020.03.001.
Abas S, Rodriguez Arevalo S, Bagan A, Grinan Ferre C, Vasilopoulou F, Brocos Mosquera I, et al. Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I-2 Receptor Ligands for Alzheimer's Disease. J Med Chem. 2020; 63(7): 3610-3633. DOI:10.1021/acs.jmedchem.9b02080.
de Salas Quiroga A, Garcia Rincon D, Gomez Dominguez D, Valero M, Simon Sanchez S, Paraiso Luna J, et al. Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure. Neuropsychopharmacology. 2020; 45(5): 877-886. DOI:10.1038/s41386-020-0621-3.
Nunez A, Vialou V, Meana JJ, Callado LF, Erdozain AM. Study of the role of the matricellular protein hevin in major depression. Eur Neuropsychopharmacol. 2020; 31: 8-9. DOI:10.1016/j.euroneuro.2019.12.011.
Muneta Arrate I, Diez Alarcia R, Horrillo I, Meana JJ. Pimavanserin exhibits serotonin 5-HT2A receptor inverse agonism for Galphai1- and neutral antagonism for Galphaq/11-proteins in human brain cortex. Eur Neuropsychopharmacol. 2020; 36: 83-89. DOI:10.1016/j.euroneuro.2020.05.004.
Vidal Domenech F, Riquelme G, Pinacho R, Rodriguez Mias R, Vera A, Monje A, et al. Calcium-binding proteins are altered in the cerebellum in schizophrenia. PLoS One. 2020; 15(7): 230400-230400. DOI:10.1371/journal.pone.0230400.
Lopez Atanes M, Recio Barbero M, Saenz Herrero M. Are Women Still "the Other"? Gendered Mental Health Interventions for Health Care Workers in Spain During COVID-19. Psychol Trauma. 2020; 12: 243-244. DOI:10.1037/tra0000751.
Recio Barbero M, Saenz Herrero M, Segarra R. Deafness and Mental Health: Clinical Challenges During the COVID-19 Pandemic. Psychol Trauma. 2020; 12: 212-213. DOI:10.1037/tra0000729.
Oliveira da Cruz JF, Ioannidou C, Pagano Zottola AC, Muguruza C, Gomez Sotres P, Fernandez M, et al. Sex-dependent pharmacological profiles of the synthetic cannabinoid MMB-Fubinaca. Addict Biol. 2020; 26(3). DOI:10.1111/adb.12940.
Blasco Fontecilla H, Herranz Herrer J, Ponte Lopez T, Gil Benito E, Donoso Navarro E, Hernandez Alvarez E, et al. Serum beta-endorphin levels are associated with addiction to suicidal behavior: A pilot study. Eur Neuropsychopharmacol. 2020; 40: 38-51. DOI:10.1016/j.euroneuro.2020.07.010.
Martinez Peula O, Rivero G, Morentin B, Callado LF, Javier Meana J, Ramos Miguel A. HISTONE H3 AND H4 POST-TRANSLATIONAL REGULATION IN SCHIZOPHRENIA POSTMORTEM BRAIN: EFFECT OF ANTIPSYCHOTIC TREATMENT. Schizophr Bull. 2020; 46: 107-107
Odagaki Y, Kinoshita M, Javier Meana J, Callado LF, Garcia Sevilla JA. Fundamental features of receptor-mediated Galphai/o activation in human prefrontal cortical membranes: A postmortem study. Brain Res. 2020; 1747: 147032-147032. DOI:10.1016/j.brainres.2020.147032.
Sanjuan J, Helga Castro Martinez X, Garcia Marti G, Gonzalez Fernandez J, Sanz Requena R, Maria Haro J et al. FOXP2expression and gray matter density in the male brains of patients with schizophrenia. Brain Imaging Behav. 2021; 15(3): 1403-1411. DOI:10.1007/s11682-020-00339-x.
Morentin B, Suarez Mier MP, Monzo A, Ballesteros J, Molina P, Lucena J. Sports-related sudden cardiac death in Spain. A multicenter, population-based, forensic study of 288 cases. Rev Esp Cardiol (Engl Ed). 2020; 74(3): 225-232. DOI:10.1016/j.rec.2020.05.044.
Valle Leon M, Callado LF, Aso E, Cajiao Manrique MM, Sahlholm K, Lopez Cano M, et al. Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia. Neuropsychopharmacology. 2020; 46(3): 665-672. DOI:10.1038/s41386-020-00872-9.
Odagaki Y, Kinoshita M, Meana JJ, Callado LF, Garcia Sevilla JA. 5-HT2A receptor-mediated G alpha(q/11) activation in psychiatric disorders: A postmortem study. World J Biol Psychiatry. 2020; 22(7): 505-515. DOI:10.1080/15622975.2020.1839967.
Abas S, Rodriguez Arevalo S, Bagan A, Grinan Ferre C, Vasilopoulou F, Brocos Mosquera I, et al. Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I-2 Receptor Ligands for Alzheimer's Disease (vol 63, pg 3610, 2020). J Med Chem. 2020; 63(18): 10529-10529. DOI:10.1021/acs.jmedchem.0c01324.
Brocos Mosquera I, Gabilondo AM, Meana JJ, Callado LF, Erdozain AM. Spinophilin expression in postmortem prefrontal cortex of schizophrenic subjects: Effects of antipsychotic treatment. Eur Neuropsychopharmacol. 2020; 42: 12-21. DOI:10.1016/j.euroneuro.2020.11.011.
McMullan M, Kelly B, Mihigo HB, Keogh AP, Rodriguez F, Brocos Mosquera I, et al. Di-aryl guanidinium derivatives: Towards improved alpha2-Adrenergic affinity and antagonist activity. Eur J Med Chem. 2020; 209: 112947-112947. DOI:10.1016/j.ejmech.2020.112947.
Prischich D, Gomila AMJ, Milla Navarro S, Sanguesa G, Diez Alarcia R, Preda B, et al. Adrenergic modulation with photochromic ligands. Angew Chem Int Ed Engl. 2020; 60(7): 3625-3631. DOI:10.1002/anie.202010553.
Recio Barbero M, Cabezas Garduno J, Zabala A, Ferreiro M, Ugarte A, Ruiz Irastorza G, et al. Neuropsychiatric symptoms in patients with systemic lupus erythematosus: prevalence and its impact on quality of life. Eur Neuropsychopharmacol. 2020; 40: 211-212. DOI:10.1016/j.euroneuro.2020.09.276.
Muguruza C, Cordero N, Meana JJ, Ortega JE. A novel double-hit animal model of schizophrenia: behavioural assessment in male and female mice. Eur Neuropsychopharmacol. 2020; 40: 53-54. DOI:10.1016/j.euroneuro.2020.09.074.
Recio Barbero M, Cabezas Garduno J, Fuertes Soriano S, Lopez Atanes M, Gonzalez Briceno JP, Mentxaka O, et al. Paliperidone palmitate long-acting formulations in recent-onset psychosis: a retrospective, non-interventional study. Eur Neuropsychopharmacol. 2020; 40: 320-321. DOI:10.1016/j.euroneuro.2020.09.413.
Lopez Atanes M, Recio Barbero M, Fuertes Soriano S, Cabezas Garduno J, Gonzalez Briceno JP, Segarra Echevarria R, et al. Potential cytochrome P450 psychotropic drug interactions in an in-patient psychiatric population. Eur Neuropsychopharmacol. 2020; 40: 276-276. DOI:10.1016/j.euroneuro.2020.09.359.
Brocos Mosquera I, Gabilondo AM, Meana JJ, Erdozain AM, Callado LF. Alteration of G-alpha protein subtypes expression in postmortem prefrontal cortex of subjects with schizophrenia. Eur Neuropsychopharmacol. 2020; 40: 334-335. DOI:10.1016/j.euroneuro.2020.09.431.
Salgueiro M, Segarra R. Long-acting injectable second-generation antipsychotics in first-episode psychosis: a narrative review. Int Clin Psychopharmacol. 2019; 34(2): 51-56. DOI:10.1097/YIC.0000000000000249.
Morentin B, Callado LF. Sudden cardiac death associated to substances of abuse and psychotropic drugs consumed by young people: A population study based on forensic autopsies. Drug Alcohol Depend. 2019; 201: 23-28. DOI:10.1016/j.drugalcdep.2019.03.021.
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Neus Fullana M, Ferres Coy A, Ortega JE, Ruiz Bronchal E, Paz V, Javier Meana J, et al. Selective Knockdown of TASK3 Potassium Channel in Monoamine Neurons: a New Therapeutic Approach for Depression. Mol Neurobiol. 2019; 56(4): 3038-3052. DOI:10.1007/s12035-018-1288-1.
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Munarriz Cuezva E, Prades R, Urigueen L, Royo S, Giralt E, Tarrago T, et al. The prolyl oligopeptidase inhibitor IPR19 improves cognitive deficits in schizophrenia-like mouse models. Eur Neuropsychopharmacol. 2015; 25(2): 479-479. DOI:10.1016/S0924-977X(15)30651-9.
Prades R, Munarriza Cuezva E, Urigueen L, Royo S, Giralt E, Meana J, et al. Selective prolyl oligopeptidase inhibition by IPR19 as a new pharmacological treatment of the cognitive impairment associated with schizophrenia. Eur Neuropsychopharmacol. 2015; 25(2): 479-480. DOI:10.1016/S0924-977X(15)30652-0.
Kelly B, McMullan M, Muguruza C, Ortega JE, Meana JJ, Callado LF, et al. alpha(2)-Adrenoceptor Antagonists: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of Pyridinoguanidine, Pyridino-2-aminoimidazoline and Their Derivatives. J Med Chem. 2015; 58(2): 963-977. DOI:10.1021/jm501635e.
Arteaga O, Revuelta M, Urigueen L, Alvarez A, Montalvo H, Hilario E. Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats. PLoS One. 2015; 10(11). DOI:10.1371/journal.pone.0142424.
Javier Meana J, Callado LF, Morentin B. Do post-mortem brain studies provide useful information for Psychiatry?. Rev Psiquiatr Salud Ment. 2014; 7(3): 101-103. DOI:10.1016/j.rpsm.2014.05.001.
Rivero G, Gabilondo AM, García Sevilla JA, La Harpe R, Callado LF, Meana JJ. Increased alpha(2)- and beta(1)-adrenoceptor densities in postmortem brain of subjects with depression: Differential effect of antidepressant treatment. J Affect Disord. 2014; 167: 343-350. DOI:10.1016/j.jad.2014.06.016.
Gil Pisa I, Cebrián C, Ortega JE, Meana JJ, Sulzer D. Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain. J Neuroinflamm. 2014; 11: 128-128. DOI:10.1186/1742-2094-11-128.
García Fuster MJ, Díez Alarcia R, Ferrer Alcón M, La Harpe R, Meana JJ, García Sevilla JA. FADD ADAPTOR AND PEA-15/ERK1/2 PARTNERS IN MAJOR DEPRESSION AND SCHIZOPHRENIA POSTMORTEM BRAINS: BASAL CONTENTS AND EFFECTS OF PSYCHOTROPIC TREATMENTS. Neuroscience. 2014; 277: 541-551. DOI:10.1016/j.neuroscience.2014.07.027.
Muguruza C, Miranda Azpiazu P, Díez Alarcia R, Morentin B, González Maeso J, Callado LF, et al. Evaluation of 5-HT2A and mGlu(2/3) receptors in postmortem prefrontal cortex of subjects with major depressive disorder: Effect of antidepressant treatment. Neuropharmacology. 2014; 86: 311-318. DOI:10.1016/j.neuropharm.2014.08.009.
Erdozain AM, Callado LF. Neurobiological alterations in alcohol addiction: a review. Adicciones. 2014; 26(4): 360-370. DOI:10.20882/adicciones.40.
O'Donovan DH, Muguruza C, Callado LF, Rozas I. Guanidine-based alpha(2)-adrenoceptor ligands: Towards selective antagonist activity. Eur J Med Chem. 2014; 82: 242-254. DOI:10.1016/j.ejmech.2014.05.057.
Morentin B, Ballesteros J, Callado LF, Javier Meana J. Recent cocaine use is a significant risk factor for sudden cardiovascular death in 15-49-year-old subjects: a forensic case-control study. Addiction. 2014; 109(12): 2071-2078. DOI:10.1111/add.12691.
Fernandez C, Callado LF, Giron R, Sanchez E, Erdozain AM, Antonio Lopez Moreno J, et al. Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results. Drug Des Dev Ther. 2014; 8: 263-277. DOI:10.2147/DDDT.S55045.
Erdozain AM, Morentin B, Bedford LYNN, King E, Tooth D, Brewer C, et al. Alcohol-Related Brain Damage in Humans. PLoS One. 2014; 9(4). DOI:10.1371/journal.pone.0093586.
Gabilondo AM. EVALUATION EXPERIENCE IN RESEARCH PROJECTS. Basic Clin Pharmacol Toxicol. 2014; 115(2, SI): 3-4
Bustillo M, Alonso M, Gonzalez Pinto A, Segarra R, Zabala A, Roman S, et al. Plasma levels of risperidone in relation to dose, clinical improvement and side-effects in first-episode psychosis. Eur Neuropsychopharmacol. 2014; 24(2): 505-506. DOI:10.1016/S0924-977X(14)70809-0.
Ballesteros J, Guillen V, Zabala A, Santos B, Rueda JR, Sola I. Clinical outcomes in schizophrenia treated with donepezil in combination with antipsychotics. Value Health 2013;16:542. FI: 2,191(Q1). ( Meeting Abstract)
Fernández-Pastor B, Ortega JE, Meana JJ. Involvement of serotonin 5-HT3 receptors in the modulation of noradrenergic transmission by serotonin reuptake inhibitors: a microdialysis study in rat brain. Psychopharmacology. 2013;229:331-44. FI: 4,061(Q1)
Ormaza M, Fernandez L, Lafuente S, Corso M, Schiller F, Xu B, et al. LaAu2 and CeAu2 surface intermetallic compounds grown by high-temperature deposition on Au(111). Phys Rev B. 2013;88: -0. FI: 3,767(Q1)
Meana JJ. Agonist signal trafficking at serotonin 5-ht2a receptor in human brain: implications for schizophrenia and antipsychotic treatment. Basic Clin Pharmacol Toxicol. 2013;113:6. FI: 2,124(Q3). ( Meeting Abstract)
Meana JJ, Fernandez-Pastor B, Ortega JE, Grandoso L, Castro E, Ugedo L, et al. Chronic citalopram administration desensitizes prefrontal cortex but not somatodendritic a2-adrenoceptors in rat brain. Basic Clin Pharmacol Toxicol. 2013;113:17. FI: 2,124(Q3). ( Meeting Abstract)
Meana JJ, Miranda-Azpiazu P, Muguruza C, Diez-Alarcia R, Callado LF, Gonzalez-Maeso J. Different pharmacological properties of ketanserin and altanserin on serotonin 5-ht2a receptors in postmortem human brain: interest for schizophrenia studies. Basic Clin Pharmacol Toxicol. 2013;113:17-8. FI: 2,124(Q3). ( Meeting Abstract).
Muguruza C, Moreno JL, Umali A, Callado LF, Meana JJ, González-Maeso J. Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects. Eur Neuropsychopharmacol. 2013;23:852-64. FI: 4,595(Q1)
Muguruza C, Lehtonen M, Aaltonen N, Morentin B, Meana JJ, Callado LF. Quantification of endocannabinoids in postmortem brain of schizophrenic subjects. Schizophr Res. 2013;148:145-50. FI: 4,590(Q1)
Pinacho R, Villalmanzo N, Roca M, Iniesta R, Monje A, Haro JM, et al. Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: A pilot study of relationship to negative symptoms. J Psychiatr Res. 2013;47:926-34. FI: 4,066(Q1)
Ortega JE, Gonzalez-Lira V, Horrillo I, Herrera-Marschitz M, Callado LF, Meana JJ. Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain. Eur J Pharmacol. 2013;709:13-9. FI: 2,592(Q2)
Ramos-Miguel A, Meana JJ, García-Sevilla JA. Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications. Int J Neuropsychopharmacol. 2013;16:683-9. FI: 5,641(Q1)
Ojeda N, Peña J, Bengoetxea E, García A, Sánchez P, Elizagárate E, et al. Evidence of the effectiveness of cognitive rehabilitation in psychosis and schizophrenia with the REHACOP programme Reply. Rev Neurol. 2013;56:400. FI: 1,179(Q4)
Rivero G, Gabilondo AM, García-Sevilla JA, Callado LF, La Harpe R, Morentin B, et al. Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment. Psychopharmacology. 2013;226:177-88. FI: 4,061(Q1)
Fernández-Fernández C, Decara J, Bermúdez-Silva FJ, Sánchez E, Morales P, Gómez-Cañas M, et al. Description of a Bivalent Cannabinoid Ligand with Hypophagic Properties. Arch Pharm. 2013;346:171-9. FI: 1,540(Q2)
Muguruza C, Rodríguez F, Rozas I, Meana JJ, Urigüen L, Callado LF. Antidepressant-like properties of three new alpha 2-adrenoceptor antagonists. Neuropharmacology. 2013;65:13-9. FI: 4,114(Q1)
Urigüen L, Gil-Pisa I, Munarriz-Cuezva E, Berrocoso E, Pascau J, Soto-Montenegro ML, et al. Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia. Transl Psychiatr. 2013;3:e221 FI: 0,000(Q0)
Alba-Delgado C, Llorca-Torralba M, Horrillo I, Ortega JE, Mico JA, Sánchez-Blázquez P, et al. Chronic Pain Leads to Concomitant Noradrenergic Impairment and Mood Disorders. Biol Psychiatry. 2013;73:54-62. FI: 9,247(Q1)
Tesis del grupo
Autor/a: Rocío Barrena Barbadillo. Título: Menús escolares en el área metropolitana de Bilbao: un análisis de su adecuación nutricional y de su ingesta. Directores/as: Iñaki X Irastorza Terradillos, Elena Rodríguez Álvarez.
Autor/a: Amaia Núñez del Moral. Título: Hevin proteina matrizelularraren parte-hartzea alkoholismoan: postmortem giza garunean eta animalia-erreduetan burututako lana. Directores/as: Luis Felipe Callado Hernando, Amaia Maite Erdozain Fernández. URL: http://hdl.handle.net/10810/59737.
Autor/a: Natalia Cordero Ruiz. Título: Characterization of a double-hit mouse model of schizophrenia. Focus on inflammatory and epigenetic processes, pharmacological modulation and sex bias. Directores/as: Jorge Ortega Calvo, Carolina Muguruza Millán. URL: http://hdl.handle.net/10810/60053.
Autor/a: María Recio Barbero. Título: Exploración de las alteraciones neuropsiquiátricas cognitivas y neuroinflamatorias el lupus eritematoso sistémico. Directores/as: Rafael Segarra Echevarría, Margarita Sáenz Herrero.
Autor/a: Ines Ibarra Lecue. Título: Molecular mechanisms underlying cannabis abuse and schizophrenia: Focus on 5-HT2A receptors and Akt/mTOR signaling pathway. Directores/as: Dra. Leyre Urigüen Echevarría, Dr. Luis Felipe Callado Hernando. URL: http://hdl.handle.net/10810/50298.
Autor/a: Iria Brocos Mosquera. Título: Estudio de los receptores adrenérgicos α2 y la proteína espinofilina en la corteza prefrontal postmortem de sujetos con esquizofrenia. Directores/as: Dr. Luis Felipe Callado Hernando. URL: http://hdl.handle.net/10810/52814.
Autor/a: Ines Ibarra Lecue. Título: Molecular mechanisms underlying cannabis abuse and schizophrenia: Focus on 5-HT2A receptors and Akt/mTOR signaling pathway. Directores/as: Dra. Leyre Urigüen Echevarría, Dr. Luis Felipe Callado Hernando. URL: http://hdl.handle.net/10810/50298.
Autor/a: Daniel Betancor Pérez. Título: "Estudio sobre identidad de género y". Directores/as: Dr. Juan Francisco Artaloytia Usobiaga , Dr. Rafael Segarra Echebarría.
Autor/a: Ohiane Mentxaka Solozabal. Título: "Predicción de la cesárea mediante una combinación de marcadores ecográficos y de historia clínica". Directores/as: Dr. Rafael Segarra Echebarria , Dr. Jon García Ormaza.
Autor/a: Jon García Ormaza. Título: Suicidio y desempleo: Barakaldo 2003-2014. Director/a: Dr. José Ignacio Eguiluz Uruchurtu, Dr. Rafael Segarra Echevarria. UPV/EHU
Autor/a: Mariana Bustillo Iceta. Título: Utilidad de la monitorización terapéutica de antipsicóticos de segunda generación en la práctica clínica de los primeros episodios psicóticos. Director/a: Dr. Rafael Segarra Echebarría, Dra. Arantzazu Zabala Rabadán. UPV/EHU
Autor/a: Eva Munarriz Cuezva. Título: Caracterización de las proteínas del complejo SNARE en esquizofrenia y su tratamiento. Director/a: Dra. Leyre Urigüen Echeverría, Dr. José Javier Meana Martínez. UPV/EHU